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The act of when you are about to ejaculate while performing a penetration sexual act in which you pull out of your partner(s) and proceed to smack your genitalia against the gluteus maximus of your partner while they take the most atrocious bowel movement on your penis which you then proceed to swing your penis covered in feces while timing it exactly when you ejaculate on to your partner's face causing a feces and sperm collision while yelling "Home run!!" in the state of New Jersey.
Boyfriend: "Hey honey, I did a Jersey Home Run to your dad last night!! He now lets me have your hand in marriage."
Concerned cousin: "WHAT"
In American Football, an ill-advised or poorly-thrown deep pass with little chance of completion.
“On third and seventeen.... home run ball... and that falls nowhere near anyone. Andre Johnson was the closest thing you could call a receiver for that one, Jim...”
Doing a #2 in a public urinal.
From American Dad, season 12, episode 20, "Gift Me Liberty":
Stan: "I know you're hiding sonething!"
Dick: "(Sobs.) OK! OK! I'm the one taking dumps in the urinals. I call them 'inside-the-park home run'."
When you take a crap in the urinal. Not to be confused with the "upper decker"
Dick hit an inside the park home run.