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The term "Jojo Reference" refers to a popular media known as anime. To be specific the anime and manga series is titled "Jojo's Bizarre Adventure", when such word it utilized it's usually in meme format with it usually having something in common with a particular scene or character. Though in many memes it is usually indirectly referencing it with small similarities.
"Hey look! A crippled guy! That's a Jojo Reference!"