An endocrine disease characterized by large limbs, protruding jaw, and a prominent forehead. These physical features are due to excessive secretion of IGF-1 (insulin growth factor-1) due to a tumor at the pituitary gland. Most humans and animals who have acromegaly are of unusually large stature and a tend to have other medical complications including resistant diabetes mellitus and cardiac disease.
"Whats up with that circus guy from Big Fish?"
-I don't know much about him other than he has acromegaly.
"Andre the Giant was the greatest wrestler/actor of all time AND has acromegaly!"
-Cool.
"I think Lurch from the Adam's family has acromegaly."
-I think you're right.
"Fuck, my cat has resistant diabetes and a high IGF level, I think he has acromegaly.
-MRI that bitch and lets find out.