Any song featuring both Lil' Wayne and T-Pain.
Boy: Dayum Who's this beat?
Girl: It's the new joint by Twayne.
12π 2π
The little bugs you find in your pubic hair
Dude, stop picking twaynes off your pubes
12π 5π
the acronym of the name Tom Wayne. Twayne is annoying most times, all times actually , sometimes less than others. You can always count on twayne to be a good friend. He also gets mad pussy
Person 1) you see that little bitch right there?
Person 2) yeah, thatβs twayne